Chromenone derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S227500, C514S232500, C514S320000, C514S365000, C514S374000, C514S397000, C514S422000, C544S242000, C544S406000, C546S135000, C546S146000, C546S283100, C548S146000, C548S159000, C548S215000, C548S250000, C548S255000, C548S262200, C548S311400

Reexamination Certificate

active

10833159

ABSTRACT:
Novel compounds of the formula Iin whichR1, R2, R3and Het are as defined herein, whichare inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of tumours, for neuroprotection and for protection of the stress proteins of the skin.

REFERENCES:
patent: 6939859 (2005-09-01), Murase et al.
patent: 7191431 (1995-07-01), None
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Hosseinimehr et al, Radioprotective Effects of 2-Imino-3-[(chromone-2-yl)carbonyl]thiazolidines against Irradiation in Mice, J. Radiat. Res., 43, 293-300 (2002).
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Wermuth “The practice of medicinal chemiistry” p. 203=208 (1996).
Braga et al. “Making crystals . . . ” Chem. Commun. p. 3635-3645 (2005).
Patani et al. “Bioisosterism: a rational . . . ” Chem. Rev. p. 3147, 3158 (1996).
Abstract of Silver Halide Photographic Sensitive Material: Toda Yuzo et al. Jul. 28, 1995.

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