Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor...

Details Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor... Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor...

2005-07-12

2005-07-12

McKane, Joseph K. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

06916832

ABSTRACT:
Novel dopamine receptor ligands of the formula:pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related dysfunction of the central or peripheral nervous system, are described. The compounds are expected to be useful in treating Parkinson's disease, improving cognition, improving memory, improving the negative symptoms of schizophrenia, improving attention-deficit hyperactivity disorder and related developmental disorders, treating substance abuse disorders, and in treating various peripheral conditions where changes in dopamine receptor occupation affects physiological function, including organ perfusion, cardiovascular function, and selected endocrine and immune system functions.

REFERENCES:
patent: 5635506 (1997-06-01), Alberts et al.
patent: 25 29 580 (1976-02-01), None
patent: 2105 323 (1982-06-01), None
patent: WO 99/11649 (1999-03-01), None

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