Liquid purification or separation – With means to add treating material – Chromatography
Reexamination Certificate
2006-11-21
2006-11-21
Therkorn, Ernest G. (Department: 1723)
Liquid purification or separation
With means to add treating material
Chromatography
C210S656000, C210S101000, C210S143000
Reexamination Certificate
active
07138051
ABSTRACT:
The present invention relates to methods, systems and software for optimising the separation of a sample of biomolecules eluted from a chromatography column in which the concentration of a second component added to an elution buffer is varied in order to form an elution buffer solution of varying second component concentration. The concentration of the elution buffer solution is held at a current value when a hold gradient event occurs and the the varying of the concentration of the elution buffer solution is restarted when a restart gradient event occurs. A hold gradient event occurs when a detector signal relating to the amount of biomolecules in the elution buffer solution rises past a first threshold and a restart gradient event occurs when the signal falls past a second threshold.
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Bentley Dwayne L.
GE Healthcare Bio-Sciences AB
Ji Yonngang
Therkorn Ernest G.
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