Chromatography method and a column material useful in said...

Details Chromatography method and a column material useful in said... Chromatography method and a column material useful in said...

2005-04-26

2005-04-26

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

With means to add treating material

Chromatography

C210S502100, C210S635000, C210S656000, C502S402000, C502S404000

Reexamination Certificate

active

06884345

ABSTRACT:
A novel sorbent suitable for use as a stationary phase in a chromatography column, the core of which consists of an organic polymer of synthetic or natural origin. Further, the carrier exhibits a plurality of covalently bonded non-aromatic zwitterionic groups on its surface. Additionally, the invention also relates to a method for purifying a particular biological macromolecule, such as a protein or a nucleic acid, by zwitterionic ion exchange chromatography as well as an ion exchange column suitable for use in the zwitterionic ion exchange chromatography.

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patent: 6039876 (2000-03-01), Yang
patent: 6074979 (2000-06-01), Hagemeyer
patent: 6238565 (2001-05-01), Hatch
patent: 6391818 (2002-05-01), Bonsel
patent: WO 9849279 (1998-11-01), None
Snyder, Introduction to Modern Liquid Chromatography, John Wiley and Sons, 1979, pp. 493-499.*
Yu (Journal of Chromatographic Science, vol. 24, May 1986, pp. 177-182.*
Yu (Journal of Chromatographic Science, vol. 27 Apr. 1989, pp. 176-185.*
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Viklund (Biotechnol. 1997, 13, 597-600).*
Hatch (Industrial and Engineering Chemistry, vol. 49 No. 11 Nov. 1957, pp. 1812-1819.*
Grote (Reactive & Functional Polymers, 35 (1997) pp. 179-196.

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