Chromatography method

Details Chromatography method Chromatography method

2011-03-08

2011-03-08

Therkorn, Ernest G (Department: 1776)

Liquid purification or separation

Processes

Chromatography

C210S656000, C210S673000, C210S198200

Reexamination Certificate

active

07901581

ABSTRACT:
The present invention relates to a simulated moving bed process, wherein at least one adsorbent is washed after binding of target compound and wherein the outlet of wash liquid from the adsorbent is subsequently passed onto another adsorbent for binding of target compound removed by the washing. In one embodiment, the method comprises binding of at least one target compound using three or more adsorbents connected in series and elution of target compound from said three adsorbents. After the binding to an adsorbent, wash liquid is passed across the adsorbent to recover desorbed and/or unbound target compound, and the outlet of such wash liquid is directed to the adsorbent after the next in the series, to which no feed has yet been added. The target compound is recovered by eluting target compound from the washed adsorbents.

REFERENCES:
patent: 3291726 (1966-12-01), Broughton
patent: 5457260 (1995-10-01), Holt
patent: 5630943 (1997-05-01), Grill
patent: 6325940 (2001-12-01), Ikeda
patent: 6652755 (2003-11-01), Ikeda
patent: 7141172 (2006-11-01), Wang et al.
patent: 2002/0108905 (2002-08-01), Ikeda
patent: 2004/0129137 (2004-07-01), Chin et al.
patent: 2007/0215534 (2007-09-01), Thommes et al.
patent: 2010/0176058 (2010-07-01), Bryntesson et al.
patent: 1 003 036 (2000-05-01), None
patent: 1 336 610 (2003-08-01), None
patent: 1 733 774 (2010-03-01), None
patent: WO 2004/018072 (2004-03-01), None
patent: WO 2004/024284 (2004-03-01), None
patent: WO 2006/116886 (2006-11-01), None
Bisschops, M. et al., “Simulated Moving Bed Technology in Biopharmaceutical Processing”, Recovery Biological Products XI, (2003) Banff, Alberta, Canada).
Heeter, G., et al., Journal of Chromatography A, 711:3-21 (1995).
Lacki, K., et al., “Protein A Counter-Current Chromatography for Continuous Antibody Purification”, ACS (2004) Anaheim, CA USA.

Affiliated with

Also associated with

Rating

Chromatography method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromatography method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromatography method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2780227