Chromatography cartridge end cap fixation

Details Chromatography cartridge end cap fixation Chromatography cartridge end cap fixation

1999-03-25

2000-09-12

Therkorn, Ernest G.

Liquid purification or separation

Processes

Chromatography

2101982, B01D 1508

Patent

active

061173290

ABSTRACT:
A method of forming a chromatography cartridge includes providing a flexible-walled tube, placing a first end cap within the tube in sealing engagement with the tube wall, forming a media bed within the tube supported by the first end cap, cooling a second end cap to thermally contract the second end cap, placing the contracted second end cap within the tube and against the media bed, and sealing the second end cap to the tube wall by thermal expansion of the second end cap upon warming. The expansion of the second end cap causes the tube wall to deform. A chromatography column includes a flexible-walled tube containing chromatography media, and an end cap positioned within the tube. The end cap has a dimension greater than an inner dimension of the tube such that the tube is locally deformed by the end cap.

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