Chromatography adsorbents utilizing mercapto heterocyclic ligand

Details Chromatography adsorbents utilizing mercapto heterocyclic ligand Chromatography adsorbents utilizing mercapto heterocyclic ligand

1995-12-22

1998-02-17

Achutamurthy, Ponnathapura

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530413, 530412, 5303871, 502401, 502402, C07K 122

Patent

active

057192693

ABSTRACT:
A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent includes: (a) a solid support material; and (b) a ligand immobilized on the surface of the solid support material, said ligand being a compound of the formula ##STR1## wherein Y.sub.1 is selected from the group of S, SCH.sub.3.sup.+, O, NH, NCH.sub.3, CH.sub.2 and CR.sub.1 R.sub.2 wherein at least one of R.sub.1 and R.sub.2 is not hydrogen; wherein each of Y.sub.2, Y.sub.3 and Y.sub.4 is selected from the group of N, NCH.sub.3.sup.+, CH, and CR wherein R is not hydrogen; and wherein at least two of Y.sub.1, Y.sub.2, Y.sub.3 and Y.sub.4 are neither CH.sub.2, CH, CR nor CR.sub.1 R.sub.2.

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