Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-03-04
2008-03-04
Gupta, Anish (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S324000, C530S417000
Reexamination Certificate
active
10939239
ABSTRACT:
The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon β-1b using size exclusion chromatography is provided. In another aspect of the invention, a method of purifying a polypeptide using size chromatography is provided. A third aspect provides a method of commercializing a polypeptide.
REFERENCES:
Gel Filtration, Principles and Methods, Amersham Biosciences, Last Modified, Aug. 9, 2002.
Pasechnik, Journal of Chromatography, (1986), 364, 359-368.
Knuth, et al., Protein Purification: Micro to Macro, 1987, Alan r. Liss, Inc., 279-305.
Konishi, 1985, Progress in HPLC, 1, 43-57.
Blank, et al., Eur. J. Biochem., 267, 5711-5716.
The Handbook of Gel Filtration, Amersham Biosciences.
Majors , R. E., LCGC 2001, 19(2), 124, 126,128, 130.
Russell-Harde et al., “The Use of Zwittergent 3-14 in the Purification of Recombinant Human Interferon-β Ser17(Beta seron)”J. Interferon and Cytokine Research 15:31-37, 1995.
Runkel et al., “Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-β (IFN-β)”Pharmaceutical Research 15(4):641-649, 1998.
Helenius et al., “Properties of Detergents”Methods in Enzymology 56:734-749, 1979.
Turro and Lei, “Spectroscopic Probe Analysis of Protein-Surfactant Interactions: The BSA/SDS System”Langmuir 11:2525-2533, 1995.
Steele et al., “Molecular Weight and Hydrodynamic Properties of Apolipoprotein B in Guanidine Hydrochloride and Sodium Dodecyl Sulfate Solutions” 254(5):1639-1643, 1979.
Takeda et al., “The Interaction of Bovine Serum Albuimin with Sodium Dodecyl Sulfate: Binding of the Surfactant and Conformational Change of the Protein Induced by the Binding”Curr. Top. Colloid Interface Sci. 1:109-135, 1997.
Crosier Walter Joseph
Riquelme Patricio T.
Victa Corazon Terciano
Wendell John Tharin
Bergin Denise S.
Chiron Corporation
Gudibande Satyanarayana R.
Gupta Anish
Harbin Alisa A.
LandOfFree
Chromatographic separation of therapeutic polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chromatographic separation of therapeutic polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromatographic separation of therapeutic polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3926426