Chromatographic separation of sugars using porous gel resins

Details Chromatographic separation of sugars using porous gel resins Chromatographic separation of sugars using porous gel resins

1991-10-23

1993-01-05

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 2101982, 2105021, 127 462, 127 463, B01D 1508

Patent

active

051768321

ABSTRACT:
The present invention is a process for the chromatographic separation of a liquid mixture comprising a first sugar component and at least one secondary component chosen from second sugars, organic acids and salts thereof, alcohols, amino acids, and inorganic salts. In the process, the liquid mixture is contacted with a stratum of a porous gel cation-exchange resin and thereafter eluted such that the first sugar component passes through the stratum at a different rate relative to the secondary components of the liquid mixture. The separation results in a first recoverable product stream rich in the first sugar component and at least one secondary product stream rich in the secondary components. The porous gel cation-exchange resin is prepared by polymerization of at least one monovinylidene monomer with a cross-linking monomer in the presence of an inert diluent. The use of such porous gel resins in the process increases kinetics, improves yields of desired sugar components, and results in a more efficient separation process. The invention is particularly applicable to separation of glucose from fructose in the preparation of high fructose corn syrup.

REFERENCES:
patent: 2500149 (1950-03-01), Boyer
patent: 2591574 (1952-04-01), McBurney
patent: 2631127 (1953-03-01), D'Alelio
patent: 2664801 (1954-01-01), Etsbein
patent: 2764564 (1956-09-01), McMaster et al.
patent: 2813810 (1957-11-01), Smith
patent: 2985589 (1961-05-01), Broughton et al.
patent: 3044905 (1962-07-01), Lefevre
patent: 3266007 (1966-08-01), Sullivan
patent: 3326875 (1967-06-01), Moore
patent: 3357158 (1967-12-01), Hollis
patent: 3458976 (1969-08-01), Hollis
patent: 3547684 (1970-12-01), Hollis et al.
patent: 3663263 (1972-05-01), Bodre et al.
patent: 3686117 (1972-08-01), Lauer
patent: 3785864 (1974-01-01), Lauer
patent: 4133696 (1979-01-01), Barker
patent: 4182633 (1980-01-01), Ishikawa et al.
patent: 4192921 (1980-03-01), Dales
patent: 4224415 (1980-09-01), Meitzner et al.
patent: 4246386 (1981-01-01), Howell et al.
patent: 4267054 (1981-05-01), Yoritomi et al.
patent: 4283499 (1981-08-01), Howell
patent: 4379751 (1983-04-01), Yoritomi
patent: 4382124 (1983-05-01), Meitzner et al.
patent: 4419245 (1983-12-01), Barrett et al.
patent: 4443267 (1984-04-01), Pansolli et al.
patent: 4564644 (1986-01-01), Harris
patent: 4724082 (1988-02-01), Boom
patent: 4837315 (1989-06-01), Kulprathipanja
Welstein and Sauer, Separation of Glucose and Fructose: Effects of Resin Characteristics on Separation, Ion Exchange Technology, Naden and Streat, eds. Soc. of Chem. Ind. (1979), pp. 466-471.
Fuller, Support-Bonded Polyaromatic Copolymer Stationary Phases for Use in Gas Chromatography, Anal. Chem., vol. 44, pp. 1747-1753 (Sep. 1972).
Moore, Gel Permeation Chromatography--A New Method for Molecular Weight Distribution of High Polymers, J. Poly. Soc., vol. 2, pp. 835-843 (1964).
Sanetra et al., The Study of Modified Poly(Styrene-Co-Divinylbenzene) by Inverse Gas Chromatographic Analysis, Die Angewandte Makromolekulare Chemie, vol. 140, pp. 41-50 (1986).
Janak, Application of Porapak.RTM., Porous Ethylvinylbenzene Polymers, as New Lipophilic Stationary Phases for Thin-Layer and Column Chromatography, Chemistry and Industry, pp. 1137-1138 (Jul. 1, 1967).
Horvath et al., Fast Liquid Chromatography. Investigation of Operating Parameters and the Separation of Nucleotides on Pellicular Ion-Exchangers, Anal. Chem., vol. 39, pp. 1422-1428 (1967).
Martinu et al., Selective Chromatographic Separation of Aromatic Hydrocarbons and Their Hydrogenated Derivatives on Porapak T, J. Chromatog., vol. 65, pp. 477-485 (1967).
Ackers, Analytical Gel Chromatography of Proteins, Advances in Protein Chemistry, vol. 24, pp. 343-446 (1970).
Bly, Gel Permeation Chromatography, Science, vol. 168, pp. 527-533 (1970).
Biesser and de Rosset, Continuous Countercurrent Separation of Saccharides with Inorganic Adsorbents, Die Starke, Hahrg. 1977, No. 11, pp. 392-397.
Food Processing, Jul. 1979, pp. 74-75.
Chemical Engineering, Jan. 24, 1983, pp. 50-52.
Wankat, Large-Scale Adsorption and Chromatography, CRC Press, Inc., Boca Raton, Fla., (1986), pp. 1-93.
Schildknecht, Polymer Processes, Interscience Publishers, Inc., New York, Chapter III, p. 69-109 (1956).
Helfferich, Ion Exchange, (McGraw-Hill 1962), pp. 35-36.
John Wiley, Mike's Laboratory Handbook of Chromatography and Allied Methods, New York, 1979, pp. 276-277 and 286-287.
Barker et al., Separation of Fructose from Carbohydrate Mixtures by Semi-Continuous Chromatography, Chemical Industries, p. 817, Nov. 17, 1983.
Ghim et al., Adsorption Characteristics of Glucose and Fructose in Ion-Exchange Resin Columns, Ind. Eng. Chem. Fundam. (1982), vol. 21, pp. 369-374.

Affiliated with

Also associated with

Rating

Chromatographic separation of sugars using porous gel resins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromatographic separation of sugars using porous gel resins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromatographic separation of sugars using porous gel resins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2389551