Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1987-12-03
1989-10-17
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530322, 530344, C07K 114
Patent
active
048748439
ABSTRACT:
This invention relates to a new chromatographic process for purifying fermentation products, particularly the antibiotic LY146032, from fermentation broths by use of a reverse phase non-functional resin.
In the process of this invention the resin is loaded with the compound in the aqueous phase, the water then is removed from the resin and the resin converted to the organic phase for the resolution step. This process is applicable to purifying compounds which are adsorbed on reverse phase non-functional resins.
REFERENCES:
patent: 3515717 (1970-06-01), Cha et al.
patent: 4208403 (1980-06-01), Hamill et al.
patent: 4440753 (1984-04-01), McCormick et al.
patent: 4537717 (1985-08-01), Abbott et al.
patent: 4719287 (1988-01-01), Login et al.
Leaflet "Isolation of Antibiotics from Fermentation Broths by DIAION HP 20, A Synthetic Adsorbent", Mitsubishi Chemical Industries Limited, pp. 1-22.
Grieser et al., "Liquid Chromatography on a Porous Polystyrene--Divinylbenzene Support", Analytical Chemistry, vol. 45, No. 8, Jul. 1973, pp. 1348-1353.
Eli Lilly and Company
Lee Lester L.
Tucker Mary Ann
Whitaker Leroy
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