Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-10-11
2000-01-25
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
422 681, 422 72, 436506, 436518, 436528, 436529, 436 13, 436825, 530413, 530868, 4352871, 4352886, 435962, 435975, G01N 33543, G01N 33548, G01N 33564, G01N 3380
Patent
active
060177217
ABSTRACT:
The invention provides a new method for antiglobulin testing from serum of a potential blood transfusion recipient in which warm autoantibodies are removed from serum so as to allow identification of alloantibodies present. The method involves contacting serum from a patient with one or more ligands that bind warm autoantibodies but do not bind alloantibodies, separating the non-bound serum components from the bound warm autoantibodies, and using the warm autoantibody-depleted serum in antiglobulin testing. Suitable ligands include phospholipids, the polar head groups of phosphoglycerides, and naturally occurring and synthetic analogues of these molecules.
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Chin Christopher L.
Grun James L.
The United States of America as represented by the Department of
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