Chromanylurea compounds that inhibit vanilloid receptor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S307000, C514S311000, C514S320000, C514S405000, C514S456000, C544S151000, C546S139000, C546S152000, C546S184000, C548S361100, C549S404000

Reexamination Certificate

active

07812019

ABSTRACT:
Compounds that are antagonists of the VR1 receptor, having formula (I)or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

REFERENCES:
patent: 5374643 (1994-12-01), Atwal et al.
patent: WO-03097586 (2003-11-01), None
patent: WO-2004078744 (2004-09-01), None
patent: WO-2007050732 (2007-05-01), None
Patani et al. “Bioisosterism: A Rational Approach in Drug Design” Chemical Reviews, 1996, vol. 96, pp. 3147-3176.
Bognar et al. “Flavonoids, XII. Synthesis of 4-Ureido-flavan and Di-(4-flavanyl)-urea” Acta. Chim. Hung. Trans, 1963, vol. 35, pp. 223-224.
Caterina et al., “Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor,”Science288:306-313 (2000).
Caterina et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway,”Nature389:816-824 (Oct. 23 1997).
Caterina et al., “The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway,”Annu. Rev. Neurosci. 24:487-517 (2001).
Collier et al., “The Abdominal Constriction Response and its Suppression by Analgesic Drugs in the Mouse,”Br. J. Pharmacol. Chemother. 32:295-310 (1968).
Dade, J., “Synthesis of 2-Substituated Trifluoromethylquinolines for the Evaluation of Leishmanicidal Activity”,Chem. Pharm. Bull., vol. 49(4), pp. 480-483, (2001).
Davis et al., “Vanilloid Receptor-1 is Essential for Inflammatory Thermal Hyperalgesia,”Nature405:183-187 (2000).
Fowler, “Intravesical Treatment of Overactive Bladder,”Urology55(Supplement 5A):60-64 (2000).
Hayes et al., “Cloning and Functional Expression of a Human Orthologue of Rat Vanilloid Receptor-1”,Pain88:205-215 (2000).
Nolano et al., “Topical Capsaicin in Humans: Parallel Loss of Epidermal Nerve Fibers and Pain Sensation,”Pain81:135-145 (1999).
Pircio, et al., “A New Method for the Evaluation of Analgesic Activity using Adjuvant-Induced Arthritis in the Rat”Eur J. Pharmacol. vol. 31(2) pp. 207-215 (1975).
Bognar rezso et al., “Flavanoids XII. Synthesis of 4-ureldoflavan and bis (4flavanyl) urea,” Acts Chim Acad. Sci, 1963, 223-224, vol. 35.
Database Beilstein Beilstein Institute for Organic Chemistry, Frank Furt-Main, DE; XP002507218 Database accession No. brn 355828 abstract and Webster et al: J.Chem.Soc. , 1965, pp. 4785-4789.
International Search Report for application No. PCT/US05/042545, Mailed on Feb. 19, 2009, 3 pages.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chromanylurea compounds that inhibit vanilloid receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromanylurea compounds that inhibit vanilloid receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromanylurea compounds that inhibit vanilloid receptor... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4172612

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.