Chromanyl glycines

Details Chromanyl glycines Chromanyl glycines

1982-04-02

1985-06-04

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549349, 549361, 549433, 549355, 549404, 549467, 549359, 560 10, 560427, C07D30782, C07D31168

Patent

active

045216070

ABSTRACT:
New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen, halogen, lower alkyl, hydroxyl, lower alkyloxy or aralkyloxy, or R.sup.1 and R.sup.2 jointly represent lower alkylenedioxy; R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl or --CH.sub.2 SR.sup.7 (R.sup.7 represents hydrogen or acyl); R.sup.6 represents hydrogen or acyl, or R.sup.6 and R.sup.7 jointly represent a single bond; X represents --CH.sub.2 --, --O-- or >N--R.sup.8 (R.sup.8 represents hydrogen, acyl or lower alkyl); and n represents 2, 3 or 4, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

REFERENCES:
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4116962 (1978-09-01), Ondetti et al.
patent: 4256761 (1981-03-01), Suh et al.

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