Chromanone derivatives

Details Chromanone derivatives Chromanone derivatives

1979-03-13

1981-04-14

Chan, Nicky

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239A, 260239E, 260239EP, 260239B, 260239BE, 260239BF, 26032636, 2603265D, 2603265SF, 260333, 2603452, 424267, 424274, 424275, 424283, 546 17, 549 5, 549 6, 549 9, 549 13, 549 60, A61K 3135, C07D31122

Patent

active

042619882

ABSTRACT:
Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R.sup.1 and R.sup.2 independently denote radicals including hydrogen, alkyl, aryl and heterocyclic radical or together complete a carbocyclic or heterocylic ring, R.sup.3 denotes a radical ##STR2## in which R.sup.9, R.sup.10 and R.sup.11 include hydrogen, cyano, nitro, alkyl and aryl or, in pairs, complete carbocyclic rings, X denotes cyano, nitro or substituted carbonyl, sulphonyl or phosphonyl group, R.sup.4 is hydrogen or a radical defined for R.sup.1 or R.sup.3, and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 include hydrogen, nitro, cyano, carboxyl, alkyl and aryl or, in pairs, complete carbocyclic rings, with the proviso that R.sup.1 and R.sup.9 are not both phenyl if X denotes CO--C.sub.6 H.sub.6. The compounds exhibit considerably higher hypocholesterolaemic activity than the known clofibrate and in addition exhibit a pronounced nutritive effect, e.g., in a medicated fodder or premix.

REFERENCES:
patent: 3410851 (1968-11-01), Stauffer
patent: 3419560 (1968-12-01), Bernstein et al.
patent: 3704323 (1972-11-01), Krapcho
patent: 3753985 (1973-08-01), Gavin et al.
patent: 3825539 (1974-07-01), Freedman

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