Chroman derivatives, medicaments and use in therapy

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S457000

Reexamination Certificate

active

08080675

ABSTRACT:
Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

REFERENCES:
patent: 3340276 (1967-09-01), Carney
patent: 3535344 (1970-10-01), Irmscher
patent: 4157984 (1979-06-01), Zilliken
patent: 4218489 (1980-08-01), Zilliken
patent: 4232122 (1980-11-01), Zilliken
patent: 4234577 (1980-11-01), Zilliken
patent: 4366082 (1982-12-01), Zilliken
patent: 4366248 (1982-12-01), Zilliken
patent: 4368264 (1983-01-01), Zilliken
patent: 4390559 (1983-06-01), Zilliken
patent: 4447622 (1984-05-01), Salman et al.
patent: 4644012 (1987-02-01), Tsuda et al.
patent: 4814346 (1989-03-01), Albert et al.
patent: 5059609 (1991-10-01), Eggler et al.
patent: 5280040 (1994-01-01), Labroo et al.
patent: 5389646 (1995-02-01), Labroo
patent: 5464862 (1995-11-01), Labroo et al.
patent: 5696149 (1997-12-01), Korsgaard et al.
patent: 5726202 (1998-03-01), Shalmi et al.
patent: 5756539 (1998-05-01), Skrumsager et al.
patent: 5780503 (1998-07-01), Biftu et al.
patent: 5849461 (1998-12-01), Hatakeyama et al.
patent: 5883118 (1999-03-01), Shalmi et al.
patent: 5919817 (1999-07-01), Jacobsen et al.
patent: 5958967 (1999-09-01), Jacobsen et al.
patent: 5985306 (1999-11-01), Jacobsen et al.
patent: 5994390 (1999-11-01), Jacobsen et al.
patent: 5998451 (1999-12-01), Eggler et al.
patent: 6005003 (1999-12-01), Nique
patent: 6043269 (2000-03-01), Jacobsen et al.
patent: 6316494 (2001-11-01), Jacobsen et al.
patent: 6610733 (2003-08-01), Kanbe et al.
patent: 6645951 (2003-11-01), Jo et al.
patent: 6649648 (2003-11-01), Kelly et al.
patent: 7056952 (2006-06-01), Joannon
patent: 7202273 (2007-04-01), Kelly et al.
patent: 7601855 (2009-10-01), Heaton
patent: 2009/0317490 (2009-12-01), Heaton
patent: 313295 (1989-04-01), None
patent: 0470310 (1992-12-01), None
patent: 0267155 (1998-05-01), None
patent: 0955286 (1999-11-01), None
patent: 1433013 (1976-04-01), None
patent: 2000-506507 (2000-05-01), None
patent: 2001-502706 (2001-02-01), None
patent: 2001-502711 (2001-02-01), None
patent: WO-80-02098 (1980-10-01), None
patent: 94/08986 (1994-04-01), None
patent: 94/20099 (1994-09-01), None
patent: 96/21442 (1996-07-01), None
patent: 96/21443 (1996-07-01), None
patent: 96/21444 (1996-07-01), None
patent: 96/22091 (1996-07-01), None
patent: 96/22092 (1996-07-01), None
patent: 96/22093 (1996-07-01), None
patent: 97/25035 (1997-07-01), None
patent: 97/25036 (1997-07-01), None
patent: WO-97-25038 (1997-07-01), None
patent: 98/02154 (1998-01-01), None
patent: 98/02156 (1998-01-01), None
patent: WO-98-08503 (1998-03-01), None
patent: 98/17662 (1998-04-01), None
patent: 98/18770 (1998-05-01), None
patent: 98/18771 (1998-05-01), None
patent: 98/18778 (1998-05-01), None
patent: WO-98-18772 (1998-05-01), None
patent: WO-98-18773 (1998-05-01), None
patent: WO-98-18774 (1998-05-01), None
patent: WO-98-18775 (1998-05-01), None
patent: WO-98-18776 (1998-05-01), None
patent: WO-98-18778 (1998-05-01), None
patent: WO-98-18779 (1998-05-01), None
patent: 98/25916 (1998-06-01), None
patent: 98/32437 (1998-07-01), None
patent: 98/33499 (1998-08-01), None
patent: 98/33500 (1998-08-01), None
patent: 99/49862 (1999-10-01), None
patent: 99/55898 (1999-11-01), None
patent: 99/63974 (1999-12-01), None
patent: 99/65893 (1999-12-01), None
patent: WO-00-66576 (2000-11-01), None
patent: 01/17986 (2001-03-01), None
patent: 01/26651 (2001-04-01), None
patent: 01/54699 (2001-08-01), None
patent: 02/02548 (2002-01-01), None
patent: 02/059113 (2002-08-01), None
patent: 03/016270 (2003-02-01), None
patent: 03/035635 (2003-05-01), None
patent: 03/063859 (2003-08-01), None
patent: 03/086386 (2003-10-01), None
patent: 2004/030662 (2004-04-01), None
patent: 2005/049008 (2005-06-01), None
patent: 2006/032085 (2006-03-01), None
patent: 2006/032086 (2006-03-01), None
Lawson , Chem. Abs. vol. 49 No. 29328 (1955). best availble.
B. Aggarwal, et al., “From chemoprevention to chemotherapy: common targets and common goals”, Expert Opin. Investig. Drugs, (2004), vol. 13(10): pp. 1327-1338.
T. Akimoto, et al., “Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways”, Int. J. Radiation Oncology Biol. Phys., vol. 50, No. 1, pp. 195-201, 2001.
F. Bellisarii, et al., “Tumor necrosis factor-α and cardiovascular diseases”, Ital Heart J 2001; vol. 2(6): pp. 408-417.
B. Bradbury, “Some oestrogenic 4-phenyl-substituted isoflav-3-ENS”, Australian Journal of Chemistry, vol. 6, 1953, pp. 447-449.
P. Bury, et al., “Synthesis and pharmacological evaluation of novelcis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor”, Bioorganic & Medicinal Chemistry, vol. 10, (2002), pp. 125-145.
A. Constantinou, et al., “Phenoxodiol, a novel isofavone derivative, inhibits dimethylbenz[a]anthracene(DMBA)-induced mammary carcinogenesis in female Sprague—Dawley rats”, European Journal of Cancer, vol. 39, (2003), pp. 1012-1018.
A. Constantinou, et al. “Phenoxodiol (2H-1-Benzopyran-7-0,1,3-(4-hydroxyphenyl), a Novel Isoflavone Derivative, Inhibits DNA Topoisomerase II by Stabilizing the Cleavable Complex”, Anticancer Research, vol. 22, pp. 2581-2586, (2002).
T. Dorai, et al., “Role of chemopreventive agents in cancer therapy” Cancer Letters, vol. 215, (2004), pp. 129-140.
J. Gamble, et al., “Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects”, Int. J. Cancer, vol. 118, pp. 2412-2420, (2006).
P. Hersey, et al., “How melanoma cells evade trail-induced apoptosis” Nov. 2001, vol. 1, pp. 142-150.
Hem Chandra JHA, et al., “Carbon—13- chemical shift assignments of chromones and isoflavones”, Can, J. Chem., vol. 58, pp. 1211-1219, (1980).
Y. Kakeji, et al., “Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents” Investigational New Drugs, vol. 15, pp. 39-48, 1997.
M. Kamsteeg, et al., “Phenoxodiol—an isoflavone analog- induces apoptosis in chemoresistant ovarian cancer cells” Oncogene, (2003), vol. 22, pp. 2611-2620.
B. Kang, et al., “Scientific Analysis of Formulation Theory of Chungpesagan- tang; In vitro Cytotoxicity of Cisplatin Combined with Chungpesagan-tang”, Natural Product Sciences, vol. 6(4), pp. 165-169, (2000).
S. Khoshyomn, et al., “Synergistic Action of Genistein and Ciplatin on Growth Inhibition and Cytotoxicity of Human Medulloblastoma Cells”; Pediatr. Neurosurg, 2000, vol. 33, pp. 123-131.
Y. Li, et al., “Apoptosis-Inducing Effect of Chemotherapeutic Agents Is Potentiated by Soy Isoflavone Genistein, a Natural Inhibitor of NF-KB in BxPC-3 Pancreatic Cancer Cell Line”, Pancreas, vol. 28, No. 4, pp. e90-e95, 2002.
C. McDonnell, et al., “Improvement in Efficacy of Chemoradiotherapy by Addition of and Antiangiogenic Agent in a Murine Tumor Model”, Journal of Surgical Research, Vo. 116, pp. 19-23, (2004).
R. Micheli, et al., “Coumestro, Plant Phenolics, and Synthetic Estrogens: a Correlation of Structure and Activity”, Journal of Medicinal and Pharmaceutical Chemistry, vol. 5, 1962, pp. 321-335.
Nakata, E. et al., “C225 Antiepidermal Growth Factor Receptor Antibody Enhances the Efficacy of Docetaxel Chemoradiotherapy”, Int. J. Radiation Oncology Biol. Phys., vol. 59, No. 4, pp, 1163-1173, 2004.
P. O'Dwyer, et al., “Antitumor Activity and Biochemical Effects of Aphidicolin Glycinate(NSC 303812) Alone and in Combination with Cisplatin in Vivo”; Cancer Research, vol. 54, pp. 724-729, Feb. 1, 1994.
M. O'Neill, et al., “Inducible Isoflavonoids from the Lima Bean,Phaseolus lunatus”, Phytochemistry, vol. 25, No. 6, pp. 1315-1322, 1986.
M. Rafi, et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chroman derivatives, medicaments and use in therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chroman derivatives, medicaments and use in therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chroman derivatives, medicaments and use in therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4264297

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.