Chroman derivatives as estrogenic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S399000

Reexamination Certificate

active

07846966

ABSTRACT:
The invention provides chroman compounds having formula 1wherein R1is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R4is H, Hal, CF3, OH or (1C-2C)alkyloxy; R2, R3, and R5are independently H, Hal, CF3, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.

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Hestiantoro et al., “Changes in Estrogen Receptor-α and -β in the Infundibular Nucleus of the Human Hypothalamus Are Related to the Occurrence of Alzheimer's Disease Neuropathology,” Journal of Clinical Enhocrinology & Metabolism, 89(4) pp. 1912-1925 (2004).
International Search Report, No. PCT/EP01/02144, Jul. 11, 2001.
Mosselman et al., “ERβ: identification and characterization of a novel human estrogen receptor,” FEBS Letters 392; pp. 49-53 (1996).
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