Chroman derivatives as estrogenic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S399000

Reexamination Certificate

active

10220509

ABSTRACT:
The invention provides chroman compounds having Formula (1), wherein R1is (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl, and independently R1has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R4is Hal, CF3, OH or (1C–2C)alkyloxy; R2, R3, and R5are independently H, Hal, CF3, (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.

REFERENCES:
patent: 3340276 (1967-09-01), Carney
patent: 5952364 (1999-09-01), Bryant
patent: 15 43 749 (1969-12-01), None
patent: 94 20098 (1994-09-01), None
patent: 96 21444 (1996-07-01), None
patent: 98 18771 (1998-05-01), None

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