Chroman derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549404, H61K 3135, C07D31158

Patent

active

054201519

ABSTRACT:
3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.

REFERENCES:
patent: 4683223 (1987-07-01), Trivedi
patent: 4801605 (1989-01-01), Hutchinson
patent: 4873262 (1989-10-01), Junge et al.
patent: 4971982 (1990-11-01), Attwood et al.
patent: 5026707 (1991-06-01), Nixon
patent: 5082858 (1992-01-01), Garcia et al.
patent: 5143936 (1992-09-01), Yamanaka et al.
patent: 5214156 (1993-05-01), Andersson et al.
patent: 5225596 (1993-07-01), Carlsson et al.
patent: 5286753 (1994-02-01), Schaus et al.
patent: 5306830 (1994-04-01), Andersson et al.
Lockhart, et al., Journal of Medicinal Chemistry, vol. 15, No. 8 pp. 863-865 (1972).
Hershenson, et al., "Annual Reports in Medicinal, Chemistry", D. Bailey Ed., 21:31-40, Acad. Press, N.Y., Apr. 1986.
Foye, W. "Principles of Medicinal Chemistry," 2nd ed. pp. 80-81, Lea & Febiger, Philadelphia, Feb. 1981.
SCRIP's Serotonin Report No. 1184, Jan. 1987.
Kokai, et al. "Preparation of 3-Aminodihydro[1]benzopyran and Benzothiopyran Derivatives as Seratoninergic Agonists", Chem. Abs. 107:39617j. Feb. 1987.
Traber, et al. "5.varies.HT.sub.1A receptor-related anxiolytics", TIPS, 8:432-437, Apr. 1987.
Samanin, et al. "Serotonin and the Pharmacology of Eating", Annals N.Y., Acad. Sci. 575:194-208, Feb. 1989.
Bowen, et al. "Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life", Proc. Natl. Acad. Sci. (USA) 86:9504-9508, Feb. 1989.
Dabire, et al. "Comparison of effects of some 5-HT.sub.1 agonists on blood pressure and heart rate of normotensive anaesthesized rats", Eur. J. Pharm. 140:259-266, Apr. 1987.
Archer, et al. "(+)-8-OH-DPAT and MeODMT Induced Analgesia is Antagonised by Noradrenaline Depletion", Physiol. and Beh. 39:95-102, Apr. 1987.
Hjorth, S. "Hypothermia in the Rat Induced by the Potent Serotoninergic Agent 8-OH-DPAT", J. Neur. Transm. pp. 131-135, Jun. 1985.
Kennett, et al. "Antidepressant-like action of 5-HT.sub.1A Agonists and conventional antidepressants in an animal model of depression", Eur. J. Pharm. 134:265-274, Oct. 1982.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chroman derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chroman derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chroman derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-362173

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.