Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-10-28
1995-05-30
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549404, H61K 3135, C07D31158
Patent
active
054201519
ABSTRACT:
3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.
REFERENCES:
patent: 4683223 (1987-07-01), Trivedi
patent: 4801605 (1989-01-01), Hutchinson
patent: 4873262 (1989-10-01), Junge et al.
patent: 4971982 (1990-11-01), Attwood et al.
patent: 5026707 (1991-06-01), Nixon
patent: 5082858 (1992-01-01), Garcia et al.
patent: 5143936 (1992-09-01), Yamanaka et al.
patent: 5214156 (1993-05-01), Andersson et al.
patent: 5225596 (1993-07-01), Carlsson et al.
patent: 5286753 (1994-02-01), Schaus et al.
patent: 5306830 (1994-04-01), Andersson et al.
Lockhart, et al., Journal of Medicinal Chemistry, vol. 15, No. 8 pp. 863-865 (1972).
Hershenson, et al., "Annual Reports in Medicinal, Chemistry", D. Bailey Ed., 21:31-40, Acad. Press, N.Y., Apr. 1986.
Foye, W. "Principles of Medicinal Chemistry," 2nd ed. pp. 80-81, Lea & Febiger, Philadelphia, Feb. 1981.
SCRIP's Serotonin Report No. 1184, Jan. 1987.
Kokai, et al. "Preparation of 3-Aminodihydro[1]benzopyran and Benzothiopyran Derivatives as Seratoninergic Agonists", Chem. Abs. 107:39617j. Feb. 1987.
Traber, et al. "5.varies.HT.sub.1A receptor-related anxiolytics", TIPS, 8:432-437, Apr. 1987.
Samanin, et al. "Serotonin and the Pharmacology of Eating", Annals N.Y., Acad. Sci. 575:194-208, Feb. 1989.
Bowen, et al. "Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life", Proc. Natl. Acad. Sci. (USA) 86:9504-9508, Feb. 1989.
Dabire, et al. "Comparison of effects of some 5-HT.sub.1 agonists on blood pressure and heart rate of normotensive anaesthesized rats", Eur. J. Pharm. 140:259-266, Apr. 1987.
Archer, et al. "(+)-8-OH-DPAT and MeODMT Induced Analgesia is Antagonised by Noradrenaline Depletion", Physiol. and Beh. 39:95-102, Apr. 1987.
Hjorth, S. "Hypothermia in the Rat Induced by the Potent Serotoninergic Agent 8-OH-DPAT", J. Neur. Transm. pp. 131-135, Jun. 1985.
Kennett, et al. "Antidepressant-like action of 5-HT.sub.1A Agonists and conventional antidepressants in an animal model of depression", Eur. J. Pharm. 134:265-274, Oct. 1982.
Hammarberg Eva M.
Johansson Lars G.
Ross Svante B.
Thorberg Seth-Olov
Aktiebolaget Astra
Cebulak Mary C.
Raymond Richard L.
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