Chordin-like molecules and uses thereof

Details Chordin-like molecules and uses thereof Chordin-like molecules and uses thereof

2005-06-03

2010-11-30

Romeo, David S (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S402000, C530S866000, C514S012200

Reexamination Certificate

active

07842784

ABSTRACT:
The present invention provides Chordin-Like (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing CHL polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with CHL polypeptides.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5589375 (1996-12-01), Ullrich et al.
patent: 5635489 (1997-06-01), Haley
patent: 5635603 (1997-06-01), Hansen et al.
patent: 5679783 (1997-10-01), De Robertis et al.
patent: 5693775 (1997-12-01), Nathans et al.
patent: 5986056 (1999-11-01), LaVallie et al.
patent: 2002/0197666 (2002-12-01), Jacobs et al.
patent: WO 98/40483 (1998-09-01), None
patent: WO 99/31236 (1999-06-01), None
patent: WO 99/57132 (1999-11-01), None
patent: WO 00/09551 (2000-02-01), None
Yoshitake et al. Derivation of monoclonal antibody to basic fibroblast growth factor and its application. Methods in Enzymology, vol. 198, 1991, pp. 148-157.
PubMed Database [online] National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 45 Center Drive, MSC6511, Bethesda, Maryland 20892-6511, USA. [accessed on Apr. 20, 2009]. Accessed from the Internet: http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed.
Wu et al. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest. Sep. 2003;112(6):924-34.
Alberts et al., “Molecular Biology of the Cell,” Garland Publishing, Inc., p. 5-7, 1994.
Bowie et al., “Deciphering the message in protein sequences: tolerance to amino acid substitutions,”Science247 (4948): 1306-10, Mar. 16, 1990.
Celeste et al., “Identification of Transforming Growth Factor Beta Family Members Present in Bone-Inductive Protein Purified from Bovine Bone,”Proc. Nat. Acad. Sci. USA87:9843-47, 1990.
Hogan, “Bone Morphogenetic Proteins: Multifunctional Regulators of Vertebrate Development”,Genes Dev. 10:1580-94, 1996.
Jones et al., “Signalling by TGF-Beta Family Members: Short-Range Effects of Xnr-2 and BMP-4 Contrast with the Long-Range Effects of Activin,”Curr. Biol. 6:1468-75, 1996.
Jones et al., “Establishment of a BMP-4 Morphogen Gradient by Long-Range Inhibition,”Dev. Biol. 194:12-17, 1998.
Nakayama Naoki et al., “A Novel chordin-like protein inhibitor for bone morphongenetic proteins expressed preferentially in mesenchymal cell lineages,”Dev Biol232:372-387, 2001.
NCI-CGAP. National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index. GenBank Database Accession No. AI246227, National Center for Biotechnology Information, Bethesda, MD. Jan. 28, 1999.
Ngo et al.,The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds),Springer Verlag, pp. 433 and 492-495, Aug. 1994.
Pappano et al., “Coding Sequence and Expression Patterns of Mouse Chordin and Mapping of the Cognate Mouse chrd and Human CHRD Genes,”Genomics52:236-39, 1998.
Piccolo et al., “Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4,”Cell86:589-98, 1996.
The I.M.A.G.E. Consortium [online], [retrieved on Nov. 7, 2002]. Retrieved from the internet:<URL:http://image.IInl.gov/image/html/phage.shtml>.
Wozney et al., “Novel Regulators of Bone Formation: Molecular Clones and Activities,”Science242:1528-34, 1988.
Brandon C. Improved immunocytochemical staining through the use of Fab fragments of primary antibody, Fab-specific second antibody, and Fab-horseradish peroxidase. J Histochem Cytochem. Jul. 1985; 33(7):715-719.
Larrain et al. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. Development. Feb. 2000; 127(4):821-830.

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