Chordin-like molecules and uses thereof

Details Chordin-like molecules and uses thereof Chordin-like molecules and uses thereof

2006-03-28

2006-03-28

Romeo, David S. (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S320100, C435S325000, C536S023500, C536S024100, C530S350000

Reexamination Certificate

active

07018810

ABSTRACT:
The present invention provides Chordin-Like (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing CHL polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with CHL polypeptides.

REFERENCES:
patent: 5679783 (1997-10-01), De Robertis et al.
patent: 5693775 (1997-12-01), Nathans et al.
patent: 5986056 (1999-11-01), LaVallie et al.
patent: 6783961 (2004-08-01), Edwards et al.
patent: WO 98/40483 (1998-09-01), None
patent: WO 99/31236 (1999-06-01), None
patent: WO 99/57132 (1999-11-01), None
patent: WO 00/09551 (2000-02-01), None
patent: WO 00/09551 (2000-02-01), None
Larrain et al. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. Development. Feb. 2000; 127(4):821-30.
U.S. Appl. No. 60/122,487.
NCI-CGAP. National Cancer Institute Cancer Genome Anatomy Project (CGAP), Tumor Gene Index. GenBank Database Accession No. AI246227, National Center for Biotechnology Information, Bethesda, MD. Jan. 28, 1999.
The I.M.A.G.E. Consortium [online], [retrieved on Nov. 7, 2002]. Retrieved from the Internet:<URL:http://image.IInl.gov/image/html/phage.shtml>.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495.
Alberts et al.,Molecular Biology of the Cell,pp. 5-7 (Garland Publishing, Inc., 1994).
Nakayama Naoki et al. “A Novel chordin-like protein inhibitor for bone morphongenetic proteins expressed preferentially in mesenchymal cell lineages.”Developmental Biology232: 372-387 (2001).
Celeste et al., “Identification of Transforming Growth Factor Beta Family Members Present in Bone-Inductive Protein Purified from Bovine Bone,”Proc. Nat. Acad. Sci. USA87:9843-47 (1990).
Hogan, “Bone Morphogenetic Proteins: Multifunctional Regulators of Vertebrate Development,”Genes Dev.10:1580-94 (1996).
Jones et al., “Signalling by TGF-Beta Family Members: Short-Range Effects of Xnr-2 and BMP-4 Contrast with the Long-Range Effects of Activin,”Curr. Biol.6:1468-75 (1996).
Jones et al., “Establishment of a BMP-4 Morphogen Gradient by Long-Range Inhibition,”Dev. Biol.194:12-17 (1998).
Pappano et al., “Coding Sequence and Expression Patterns of Mouse Chordin and Mapping of the Cognate Mouse chrd and Human CHRD Genes,”Genomics52:236-39 (1998).
Piccolo et al., “Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4,”Cell86:589-98 (1996).
Wozney et al., “Novel Regulators of Bone Formation: Molecular Clones and Activities,”Science242:1528-34 (1988).

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