Chondropsin-class antitumor v-atpase inhibitor compounds,...

Details Chondropsin-class antitumor v-atpase inhibitor compounds,... Chondropsin-class antitumor v-atpase inhibitor compounds,...

2007-04-17

2007-04-17

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C540S456000

Reexamination Certificate

active

10521930

ABSTRACT:
A substantially purified compound of the formula: a composition comprising a therapeutically effective amount of at least one compound of the formula, alone or in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.

REFERENCES:
patent: WO00/51589 (2000-09-01), None
patent: WO02/08231 (2002-01-01), None
Bowman et al., “Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells,”PNAS, 85, 7972-7976 (1988).
Cantrell et al., “Chondropsins A and B: Novel Tumor Cell Growth-Inhibitory Macrolide Lactams from the Marine Sponge Chondropsis sp,”J. Am. Chem. Soc., 122, 8825-8829 (2000).
Dröse et al., “Bafilomycins and Concanamycins as Inhibitors of V-ATPases AND P-ATPases,”J. Exp. Biol., 200, 1-8 (1997).
Dröse et al., “Inhibitory Effect of Modified Bafilomycins and Concanamycins on P- and V-Type Adenosinetriphosphatases,”Biochemistry, 32, 3902-3906 (1993).
Rashid et al., “Chondropsin D, a New 37-Membered-Ring Macrolide Lactam from the Marine Sponge Chondropsis Species,”J. Nat. Prod., 64, 1341-1344 (2001).
Rashid et al., “Application of High-Field NMR and Cryogenic Probe Technologies in the Structural Elucidation of Poecillastrin A, a New Antitumor Macrolide Lactam from the Sponge Poecillastra Species,”Orangic Lett., 4(19), 3293-3296 (2002).
Rashid et al., “New chondropsin macrolide lactams from marine sponges in the genus Ircinia,”Tetrahedron Lett., 42, 1623-1626 (2001).

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