Chondroprotective/restorative compositions and methods of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S002600, C514S056000, C514S062000, C424S423000, C424S134100, C424S450000, C424S484000, C424S756000, C424S499000, C424S548000, C424S639000, C424S486000, C424S488000, C536S021000, C536S054000, C536S018700, C536S055100, C536S055200

Reexamination Certificate

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06924273

ABSTRACT:
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.

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patent: 6346519 (2002-02-01), Petrus
patent: 6476005 (2002-11-01), Petito et al.
Horse Journal, “Hyaluronic Acid Rules In Severe Joint Problems,” vol. 9, No. 5: pp 3-6 (May 2002).
Balazs, EA, et al, “Matrix engineering,” Blood Coagul Fibrinolysis, vol. 2 (1): 173-8 (1991).
Shimizu, C, et al, “Histomorphometric and Biochemical Effect of Various Hyaluronans on Early Osteoarthritis,” J Rheumatology, 25(9): 1813-9 (1998).
Laurent, TC, et al, “The properties and turnover of hyaluronan,” Functions of the Proteoglycans, Ciba Fndtn Sympos, 124:9-29 (1986).
Tulamo, RM, et al, “Determination of concentration of hyaluronate in equine serum,” Am J Vet Res, V. 51(5): 740-2 (1990).
Creamer, P, et al, Novel “Drug Treatment Strategies for Osteoarthritis,” J Rheumatology, V. 20 (9):1461-3 (1993).

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