Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-09-28
1997-04-15
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514825, A61K 3119
Patent
active
056210094
ABSTRACT:
A chondroprotective agent comprising a carboxylic acid compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom or an alkyl group of 1 to 6 carbon atoms, or a cis- or trans-isomer thereof, or a pharmaceutically acceptable salt or ester thereof, and a pharmaceutically acceptable carrier is disclosed. The above compound strongly inhibits proteoglycan depletion from the chondrocyte matrix and exhibits a function to protect cartilage, and thus, is extremely effective for the treatment of arthropathy.
REFERENCES:
Indian J. Exp. Biol., "Anti-Inflammatory Action of Ferulic Acid and Its Esters in Carrageenan Induced Rat Paw Oedema Model" by A.S. Chawla et al, vol. 25, No. 3, Mar. 1987, pp. 187-189.
Acta Zool. Sin., "Ultrastructural Observation on the Effects of Ferulic Acid on the Cartilage Proteoglycans in young Rats" by B.S. Zhou et al, vol. 38, No. 1, Mar. 1992, pp. 106-107.
Wuhan Daxue Xuebao, Ziran Kexueban, "Action of Derulic Acid and Sodium Selemite on Young Rats" by B.S. Zhou et al, No. 4, 1990, pp. 93-97.
Biotechnol. Ther., "Metabolic Activation of Phenols by Stimulated Neutrophils: A Concept for a Selective Type of Anti-Inflammatory Drug" by B.A. 'T Hart et al, vol. 3, No. 3-4, 1992, pp. 119-135.
Acupunct. Electro-Ther. Res. Int. J., "A Pharmacological Study of the Anti-Inflammatory Activity of Chinese Herbs. A Review." by J. Cyong et al, vol. 7, No. 2-3, 1982, pp. 173-202.
Clin. Chim. Act., "The Effect of Uraemic Metabolites on Parathyroid Extract-Induced Bone Resorption In Vitro" by M.R. Wills et al, vol. 73, No. 1, 1976, pp. 121-125.
Niimura Koichi
Umekawa Kiyonori
Watanabe Koju
Criares Theodore J.
Kureha Chemical Industry Co. Ltd.
LandOfFree
Chondroprotective agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chondroprotective agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chondroprotective agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-361194