Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1993-04-13
1995-08-22
Parr, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, C07K 1400
Patent
active
054441579
ABSTRACT:
A novel chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF and promoting the differential potency of said cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.
REFERENCES:
Neame et al. (Jun. 15, 1990) The Journal of Biological Chemistry, vol. 265 (17). pp. 9628-9632.
Biochemical and Biophysical Research Communications. vol. 175, No. 3, 29 Mar. 1991, Duluth, Minn. US, pp. 971-977, Y. Hiraki et al. "Molecular Cloning of a New Class of Cartilage-Specific Matrix, Chondromodulin-I, Which Stimulates Growth of Cultured Chondrocytes".
Chemical Abstracts, vol. 107, No. 21, 23 Nov. 1987, Columbus, Ohio, US: abstract No. 191734, Y. Hiraki et al. "Combined effects of somatomedin-like growth factors with fibroblast growth factor epidermal growth factor in DNA synthesis in rabbit chondrocytes" p. 155, col. R; & Mol Cell Biochem. vol. 76, No. 2, 1987, The Hague, NL pp. 185-193.
Biological Abstracts.-Microfilms. Abstr. No. 53271 vol. 90, No. 5, 1990, Philadelphia, Pa. US M. Takigawa et al. `A clonal human chondrosarcoma cell line produces an anti-angiogenic antitumor factor` & Anticancer Res. 10 (2 Part A) 1990, Athens, Greece pp. 311-316.
Journal of Biological Chemistry, vol. 265, No. 17, 15 Jun. 1990, Baltimore US pp. 9628-9633; P. J. Neame et al. `An 18-kDa Glycoprotein from Bovine Nasal Cartilage`.
Hiraki Yuji
Kamizono Akihito
Kondo Jun
Suzuki Fujio
Tanaka Hideho
Arthur Lisa
Mitsubishi Kasei Corporation
Parr Margaret
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