Chondroitinase ABC I polynucleotides

Details Chondroitinase ABC I polynucleotides Chondroitinase ABC I polynucleotides

2006-12-13

2009-06-30

Nashed, Nashaat T (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S183000, C435S200000, C435S320100, C514S04400A

Reexamination Certificate

active

07553950

ABSTRACT:
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.

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