Chondroitin sulfate synthesis promoter

Details Chondroitin sulfate synthesis promoter Chondroitin sulfate synthesis promoter

2011-05-10

2011-05-10

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

C435S193000

Reexamination Certificate

active

07939065

ABSTRACT:
The invention provides a chondroitin sulfate synthesis promoter useful for the treatment of diseases such as articular disease and discopathy. The chondroitin sulfate synthesis promoter contains, as an active ingredient, chondroitin sulfate glucuronyltransferase protein and/or chondroitin sulfate N-acetylgalactosaminyltransferase-1 protein, or a gene encoding the enzyme protein(s).

REFERENCES:
“Acession No. AB081516 and SEQ ID No. 3 alignment”, Oct. 10, 2002.
Gotoh et al., “Molecular Cloning and Characterization of a Novel Chondroitin Sulfate Glucuronyltransferase That Transfers Glucuronic Ac”, “The Journal of Biological Chemistry”, Oct. 11, 2002, pp. 38179-38188, vol. 277, No. 41, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Gotoh et al., “Enzymatic Synthesis of Chondroitin with a Novel Chondroitin Sulfate N-Acetylgalactosaminyltransferase That Transfers N-A”, “The Journal of Biological Chemistry”, Oct. 11, 2002, pp. 38189-38196, vol. 277, No. 41, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Kitagawa et al., “Molecular Cloning and Expression of a Human Chondroitin Synthase”, “The Journal of Biological Chemistry”, Oct. 19, 2001, pp. 38721-38726, vol. 276, No. 42, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Sato et al., “Differential Roles of Two N-Acetylgalactosaminyltransferases, CSGaINAct-1, and a Novel Enzyme, CSGaINAcT-2”, “The Journal of Biological Chemistry”, Jan. 31, 2003, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Uyama et al., “Molecular Cloning and Expression of Human Chondroitin N-Acetylgalactosaminyltransferase”, “The Journal of Biological Chemistry”, , pp. 8841-8846, vol. 277, No. 11, Publisher: The American Society for Biochemistry and Molecular Biology, Inc., (2002).
Yada et al., “Chondroitin Sulfate Synthase-2 Molecular Cloning and Characterization of a Novel Human Glycosyltransferase Homologous to”, “The Journal of Biological Chemistry”, Aug. 8, 2003, pp. 30235-30247, vol. 278, No. 32, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Yada et al., “Chondroitin Sulfate Synthase-3 Molecular Cloning and Characterization”, “The Journal of Biological Chemistry”, Oct. 10, 2003, pp. 39711-39725, vol. 278, No. 42, Publisher: The American Society for Biochemistry and Molecular Biology, Inc.

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