Cholinergic antagonist patch

Details Cholinergic antagonist patch Cholinergic antagonist patch

1998-02-11

1999-10-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514292, 514946, 514947, A61F 1302

Patent

active

059620129

ABSTRACT:
Scopolamine is a folksy cholinergic antagonist, and is used by parasympathetic nerves in autonomic nervous neurons as an anti-motion sickness drug or an anti-emesis drug. Since the human body most effectively absorbs this drug through the postauricular skin, the drug is administered by postauricular transdermal resorption patch. The penetrability of drug is increase by adding a dermal penetrative enhancer, because the penetration ability of patch-administered drugs is usually decreased by the penetrative blockade at dermal horny layers. The present invention discloses a penetration enhancer to increase dermal absorption and penetration of the cholinergic antagonist. The present invention finds that polyethylene and amide enhance penetration, about 2.2-2.8 fold. In accordance with the present invention, a penetration enhancer is added to the formulations of transdermal patch to increase the human body's absorption of scopolamine.

REFERENCES:
patent: 5006342 (1991-04-01), Cleary et al.
patent: 5811117 (1998-09-01), Hashimoto et al.
patent: 5834010 (1998-11-01), Quan et al.

Affiliated with

Also associated with

Rating

Cholinergic antagonist patch does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cholinergic antagonist patch, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cholinergic antagonist patch will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1168618