Choline compositions and uses thereof

Details Choline compositions and uses thereof Choline compositions and uses thereof

1997-11-26

2000-11-28

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 3114

Patent

active

061536539

ABSTRACT:
The invention provides compositions that include conjugates of choline and a fatty acid, preferably cis-docosahexaenoic acid. The conjugates are useful in treating disorders resulting from cerebral ischemia including stroke.

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Schabitz WR, et al., "The Effects of Prolonged Treatment With Citicoline in Temporary Experimental Focal Ischemia", J Neurol Sci, 1996, 138(1-2); 21-25. (Abstract).
D'Orlando KJ, et al., "Citicoline (CDP-Choline): Mechanisms of Action and Effects in Ischemic Brain Injury", Neurol Res, 1995, 17(4): 281-284. Review.
Nishio K, et al., "Novel Water-Soluble Derivatives of Docosahexaenoic Acid Increase Diacyl-Glycerol Production Mediated by Phosphatidylcholine-Specific Phospholipase C", Proc Soc Exp Biol Med, 1993, 203(2): 200-208.
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