Choline binding proteins for anti-pneumococcal vaccines

Details Choline binding proteins for anti-pneumococcal vaccines Choline binding proteins for anti-pneumococcal vaccines

2004-07-28

2008-09-16

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C435S326000, C435S331000, C530S387100, C530S388100

Reexamination Certificate

active

07425327

ABSTRACT:
The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularlystreptococcus, and more particularlypneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.

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