Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2007-01-23
2007-01-23
Brumback, Brenda (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C424S009100
Reexamination Certificate
active
09704272
ABSTRACT:
Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
REFERENCES:
patent: 5725873 (1998-03-01), Cook et al.
patent: 5814316 (1998-09-01), Cook et al.
patent: WO98/57649 (1998-12-01), None
patent: WO00/18912 (2000-04-01), None
patent: WO00/34461 (2000-06-01), None
patent: WO00/55318 (2000-09-01), None
Lawn, et al, 1999, J. Clinical Investigation, 104: R25.
Berge, et al, 2000, Science, 290: 1771.
Remaley, et al, 1999, Proc. Natl. Acad. Sci., 96(22): 12685-12690.
Asztalos, et al, 2001, Atherosclerosis, 156: 217-225.
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 1993, McGraw-Hill, pp. 1484-1488.
Pettit and Gombotz, 1998, TIBTECH, 16: 343-349.
Becq, F. et al., “ABC1, an ATP Binding Cassette Transporter Required for Phagocytosis of Apoptotic Cells, Generates a Regulated Anion Flux after Expression inXenopus laevisOocytes,”The Journal of Biological Chemistry272:2695-2699 (1997).
Bodzioch, M. et al., “The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease,”Nature Genetics22:347-351 (1999).
Brooks, A. et al., “Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency,”Nature Genetics22:336-345 (1999).
Fridolfsson, A.K. et al., “Evolution of the avian sex chromosomes from an ancestral pair of autosomes,”Proc. Natl. Acad. Sci. USA95:8147-8152 (1998).
McNeish, J. et al., “High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1,”PNAS97:4245-4250 (2000).
Orso, E. et al., “Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice,”Nature Genetics24:192-196 (2000).
Poernama, F. et al., “Spontaneous high density lipoprotein deficiency syndrome associated with a Z-linked mutation in chickens,”Journal of Lipid Research31:955-963 (1990).
Poernama, F. et al., “High Density Lipoprotein Deficiency Syndrome in Chickens Is Not Assciated With an Increased Susceptibility to Atherosclerosis,”Arteriosclerosis and Thrombosis12:601-607 (1992).
Repa, J.J. et al., “Regulation and Absorption and ABC1-mediated Efflux of Cholesterol by RXR Heterodimers,”Science289:1524-1529 (2000).
Rust, S. et al., “Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1,”Nature Genetics22:352-355 (1999).
Schreyer, S.A. et al., “Hypercatabolism of Lipoprotein-Free Apolipoprotein A-I in HDL-Deficient Mutant Chickens,”Arteriosclerosis and Thrombosis14:2053-2059 (1994).
Yokoyama, H. et al., “Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing,”Am J Vet Res54:867-872 (1993).
Young, S.G. et al., “The ABCs of cholesterol efflux,”Nature Genetics22:316-318 (1999).
Hamon et al., Interleukin-1β Secretion is Impaired by Inhibitors of the Atp Binding Cassette Transporter, ABC1,Blood90:2911-2915 (1997).
Owen, James S., “Role of ABC1 gene in Cholesterol efflux and atheroprotection,”The Lancet354:1402-1403 (1999).
Schmita, et al., ATP-Binding Cassette Transporter A1(ABCA1) in Macrophages: A Dual Function in Inflammation and Lipid Metabolism?Pathobiology67:236-240 (1999).
Attie Alan D.
Brooks-Wilson Angela R.
Cook Mark
Gray-Keller Mark P.
Hayden Michael R.
Brumback Brenda
Wegert Sandra
Wisconsin Alumni Research Foundation
Xenon Genetics Inc.
LandOfFree
Cholesterol transport gene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cholesterol transport gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cholesterol transport gene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3796548