Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-10-06
1994-04-12
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514397, 514444, 514452, 514414, 546270, 5483117, 548463, 549 60, 549363, A61K 3138, A61K 3144, C07D49308
Patent
active
053026047
ABSTRACT:
Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors and thus useful as cholesterol lowering agents, antifungal agents and cancer treatment agents.
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patent: 5096923 (1992-03-01), Bergstrom et al.
Kobel and Traber, European Journal App. Microbiol. Biotechnol. 14: 237-240 (1982).
Hensens et al., J. Antibiotics, 45: 133-135 (1992).
Arison Byron H.
Byrne Kevin M.
Chen Shieh-Shung T.
Kaplan Louis
MacConnell John G.
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Raymond Richard L.
Winokur Melvin
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