Cholesterol lowering compounds

Details Cholesterol lowering compounds Cholesterol lowering compounds

1992-09-10

1993-11-02

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514414, 514406, 514397, 514382, 514374, 514365, 514338, 514333, 514321, 514256, 514253, 5142338, 5142282, 546256, 546270, 546197, 546187, 548518, 548517, 548455, 548454, 5483644, 548253, 5483117, 548236, 548204, 549363, 549310, 549229, 549 60, 549 58, 549 28, 549 23, 549 13, A61K 31335, A61K 31365, A61K 3138, A61K 3134, C07D31904, C07D40506, C07D40508, C07D40706

Patent

active

052584011

ABSTRACT:
Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.

REFERENCES:
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patent: 5096923 (1992-03-01), Bergstrom et al.
patent: 5102907 (1992-04-01), Bergstrom et al.
patent: 5132320 (1992-07-01), Bergstrom et al.
Baxter et al., J. Biol. Chem. vol. 267, 11705-11708 (1992).
Dawson et al., J. Antibiotics, 639-647 (May 1992).
Sidebottom et al., J. Antibiotics, 45, 648-657 (May 1992).

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