Cholesterol lowering compounds

Details Cholesterol lowering compounds Cholesterol lowering compounds

1993-01-19

1994-07-05

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549363, 549310, 549 60, 549 58, 549 28, 549 23, 548518, 548517, 548455, 548253, 548197, 548187, 544377, 544357, 544336, 544335, 544296, 544295, 544238, 544151, 544 61, 544 584, 514422, 514414, 514406, 514397, 514382, 514374, 514365, 514338, 514333, 514321, 514256, 514253, 5142338, 514228, A61K 31335, A61K 31365, C07D40506, C07D31904

Patent

active

053267834

ABSTRACT:
This invention is directed to compounds of formula (I) which are novel C3- or C5-acyl sulfonamide, carboxamic acid or tetrazolyl analogs of the Zaragozic acids. These compounds inhibit the enzyme squalene synthase and are useful as cholesterol lowering agents. ##STR1##

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Sidebottom et al., J. Antibiotics, 45, 648-58 (1992).
Jones et al., J. Antibiotics, 45, 1492-98 (1992).
Baxter et al., J. Biol. Chem. 267, 11705-08 (1992).

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