Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-09-02
1994-05-10
Chan, Nicky
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D31904
Patent
active
053109490
ABSTRACT:
New Zaragozic acids have been isolated from a culture of MF5465. These compounds and their derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
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Baxter et al., Squalestatin 1, A Potent Inhibitor of Squalene Synthase Which Lowers Serum Cholesterol in Vivo, J. Biol. Chem., vol. 267 pp. 11705-11708 (1992).
Dawson, M. J. et al., . . . "The Squalestatins, Novel Inhibitors of Squalene Synthase . . . ", The Journal of Antibiotics, vol. 45, No. 5, pp. 639-647 (1992).
Sidebottom, P. J. et al., . . . "The Squalestatins, Novel Inhibitors of Squalene Synthase . . . ", The Journal of Antibiotics, vol. 45, No. 5, pp. 648-658 (1992).
Dufresne Claude
Ferrell Leslie A.
Masurekar Prakash S.
Sosa Margaret S.
Zink Deborah L.
Chan Nicky
Merck & Co. , Inc.
Meredith Roy D.
Tribble Jack L.
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