Cholesterol lowering compounds

Details Cholesterol lowering compounds Cholesterol lowering compounds

1992-11-24

1994-06-21

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549363, A61K 31335, C07D49308

Patent

active

053228553

ABSTRACT:
Zaragozic acids isolated from a culture of MF5465 have been subjected to photoreaction, then derivatized at the 4-keto position. The resulting derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

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Sidebottom et al., "The Squalestatins, . . . II. Structure Elucidation", J. Antibiotics, vol. 45(5), pp. 648-658, 1992.
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