Cholesterol lowering agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549389, A61K 3135, C07D31192

Patent

active

051822989

ABSTRACT:
This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.

REFERENCES:
patent: 3914317 (1975-10-01), McGahren
patent: 4935363 (1990-06-01), Brown et al.
W. J. McGahren et al., J. Amer. Chem. Soc., 96: 1616-1617 (1974).
W. J. McGahren et al., J. Org. Chem., 41: 66-71 (1976).
K. Fukuyama et al., Tetrahedron Lett., 3: 189-190 (1976).
K. Fukurjama, J. C. S. Perkin II, 683-686 (1978).
M. S. Brown and J. L. Goldstein, Science, 232: 34-47 (1986).
P. T. S. Ma et al., Proc. Natl. Acad. Sci. USA, 83: 8370-8374 (1986).
J. L. Goldstein and M. S. Brown, Nature, 343: 425-430 (1990).

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