Cholesterol-lowering agents

Details Cholesterol-lowering agents Cholesterol-lowering agents

1991-04-12

1993-01-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

A61K 31785

Patent

active

051788543

ABSTRACT:
A method for lowering serum total cholesterol in an animal by administering to the aminal an anion-exchange resin having the monomer units respectively represented by the below-given structural formulas (I), (II), (III) and (IV) in a content of 60-95 molar % of the monomer unit (I), 0-25 molar % of the monomer unit (II), 0--30 molar % of the monomer unit (III) and 1-6 molar % of themonomer unit (IV). ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different respectively are hydrogen atom, a lower alkyl group or benzyl group, R.sup.4 is hydrogen atom, a lower alkyl group or hydroxy-methyl group and X is a halogen atom. The above-mentioned agents specifically bind with bile acid in the intestinal tract even in the presence of other acids.

REFERENCES:
patent: 3780171 (1973-06-01), Irmscher et al.
patent: 4055429 (1977-10-01), Holmes et al.
patent: 4311799 (1982-01-01), Miyake et al.
patent: 4412011 (1983-10-01), Kihara
Chemical Absracts, vol. 95, No. 9, 31 Aug. 1981, p. 125, No. 73880.
Chemical Abstracts, vol. 98, No. 16, 18 Apr. 1983, p. 373, No. 132320.

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