Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-22
1994-02-01
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, 4352541, A61K 31335, C07D31908
Patent
active
052832562
ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
REFERENCES:
patent: 4871721 (1989-10-01), Biller et al.
patent: 5025003 (1991-06-01), Biller et al.
patent: 5026554 (1991-06-01), Bartizal et al.
patent: 5053425 (1991-10-01), Bartizal et al.
patent: 5055487 (1991-10-01), Bartizal et al.
patent: 5096923 (1992-03-01), Bergstrom et al.
patent: 5102907 (1992-07-01), Bergstrom et al.
patent: 5135935 (1992-08-01), Alberts et al.
Biller et al., J. Med. Chem., 31: 1869-1871 (1988).
Poulter et al., J. Am. Chem. Soc., 111: 3734-3739 (1989).
Corey et al., J. Am. Chem. Soc., 98: 1291-1293 (1976).
Ortiz de Montellano et al., J. Med. Chem., 20: 243-249 (1977).
S. A. Biller et al., J. Med. Chem., 34: 1912 (1991).
S. A. Biller et al., J. Am. Chem. Soc., 113: 8522 (1991).
Oehlschlager et al., J. Org. Chem., 56: 3856 (1991).
Biller and Forster, Tetrahedron, 46: 6645 (1990).
Chen et al., Arch. Biochem. Biophys., 269: 544-547, Mar. 1989.
Hensens et al., J. Antibiotics, 45: 133-135 (1992).
Kobel and Traber, European Journal App. Microbiol. Biotechnol. 14: 237-240 (1982).
Baxter et al., J. Biol. Chem. 181, 267: 11705-11708 (1992).
Dawson et al., J. Antiobiotics 45: 639-647 (1992).
Sidebottom et al., J. Antibiotics 45: 648-658 (1992).
Dufresne Claude
Guarro Josep
Huang Leeyuan
Kong Yu L.
Lingham Russell B.
Chan Nicky
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Winokur Melvin
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