Cholesterol-lowering agents

Details Cholesterol-lowering agents Cholesterol-lowering agents

1993-02-25

1995-09-05

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Ion exchange resin

514452, 549263, 549328, 424 7816, A61K 31335

Patent

active

054477174

ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferass and farnesylation of the oncogene protein Ras and thus useful in treating cancer.

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patent: 5102907 (1992-04-01), Bergstrom et al.
patent: 5132320 (1992-07-01), Bergstrom et al.
Baxter et al., J. Biol. Chem 267, 11705-11708, (1992).

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