Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-03-19
1994-11-29
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, 549305, 549229, 5483117, 544148, 514397, 5142315, A61K 31335, C07D31904
Patent
active
053691253
ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
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Baxter et al., J. Biol. Chem 267, 11705-11708, (1992).
Berger Gregory D.
Bergstrom James D.
Biftu Tesfaye
Bugianesi Robert L.
Burk Robert M.
Chan Nicky
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Winokur Melvin
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