Cholesterol ester-reducing amides of hexahydroindolinols

Details Cholesterol ester-reducing amides of hexahydroindolinols Cholesterol ester-reducing amides of hexahydroindolinols

1978-03-29

1980-03-18

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

542429, A61K 3140, C07D20904

Patent

active

041940024

ABSTRACT:
Long chain fatty acid amides of styryl hexahydroindolinols in which the amido portions have ethyleneically unsaturated positions or cyclopropanyl rings, eg 1-(1-oxo-9-cis-octadecenyl)-(3aRS, 4RS, 7aRS)-4-(Z)-(3,4-dimethoxy)-styryl-hexahydro-4-indolinol, are useful as cholesterol ester-reducing agents and are obtainable by reacting corresponding long chain carboxylic acids (or derivatives thereof) with appropriate 4-styryl-4-hexahydroindolinols.

REFERENCES:
patent: 3551462 (1970-12-01), Seki et al.
patent: 3621043 (1971-11-01), Seki et al.
patent: 3728459 (1973-04-01), Seki et al.
patent: 3741999 (1973-06-01), Seki et al.
patent: 3995059 (1976-11-01), Fukumaru et al.
patent: 4129658 (1978-12-01), Berthold

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