Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1997-02-27
1999-02-16
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
514844, 514847, A61K 700
Patent
active
058717595
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/JP96/01815 filed Jul. 1, 1996.
The present invention relates to cholesterol ester clathrate and hydrous composition comprising thereof and more particular, relates to the improvement of the stability in hydrating and emulsifying said hydrous composition.
Water-holding in skin is an essential factor for keeping the skin in good condition. So, a lot of cosmetics and pharmaceutical preparations which intend the moisturizing are sold in the market, and a lot of humectants are developed. Among of these, a hydrous oily component, e.g., cholesterol ester which is excellent in hydration property and moisturizing property, are used in particularly cosmetics.
However, in case of compounding such a hydrous oily component which was included a lot of water to the cosmetics, it had some problems in stability, since water was separated at a high temperature or temperature change with the passage of time.
Therefore, for keeping the stability of the cosmetics which comprising oil and water, various surfactants has been used in separately or by combining two or more as an emulsifier.
However, ionic surfactants such as alkyl sulfate and higher fatty acid salt has an apprehension of skin irritation, in the case where they are used at high concentration. And in case of using nonionic surfactants such as polyoxyethylene type, it has a problem in solubility such that nonionic surfactants inactivate an antiseptic such as paraben.
In order to solve these problems, it has been developed techniques which uses cyclodextrin or its derivatives as an emulsifier. Namely, Japanese Unexamined Patent Publication No. Sho 58-58139 discloses the technique of emulsification by the specific process that cyclodextrin is used by combination with oil soluble surfactant. Also, Japanese Unexamined Patent Publication No. Sho 63-194726 discloses the technique which is used methylated .beta.-cyclodextrin as an assistant emulsifier.
However, the problems such as skin irritation has not solved completely, since conventional surfactants are used by combining in these techniques.
In order to solve these problems, as for the example which is obtained the emulsion cosmetics without using any surfactant, the content in Japanese Unexamined Patent Publication No. Hei 3-284611 is listed. Namely, in Japanese Unexamined Patent Publication No. Hei 3-284611, the emulsion cosmetics which comprising a hydroxyalkylated cyclodextrin, oil and water is mentioned. This emulsion cosmetics is rich in solubility and excellent in stability and safety.
However, such a cosmetics is still insufficient in the water-holding capacity for keeping the moisture, so it is desired the further improvement.
Thereupon, it has been developed the techniques used a hydroxyalkylated cyclodcxtrin which is effectively functioned to the composition as a hydrous stabilizer at the same time as an emulsifier.
However, in the water-holding of lipstick, and the like by using these techniques, the water-holding under the severe conditions such that is left for a long period of time and at 90.degree. C. in the preparation time, is still insufficient. It sometimes occurs the aggregation of coloring agent and separate into a water phase and an oil phase or an emulsion phase, it is desired the further improvement.
In view of the above-mentioned problems of the prior art, the object of the present invention is to provide a cholesterol clathrate which has an excellent stability, safety and high water-holding capacity for keeping the moisture, and has an emulsifying effect in itself, and is to provide a hydrous composition which has an excellent stability, safety and high hydrous capacity for keeping the moisture, and has extremely excellent effect which is not separated even under the severe condition such as high temperature.
As the result of diligent studies of the inventors for attaining the above-mentioned object, it has been found that cholesterol ester clathrate comprising a cholesterol ester included in a hydroxyalkylated cyclodextrin can be functioned as an excellent em
REFERENCES:
patent: 5194250 (1993-03-01), Fairhurst
patent: 5447920 (1995-09-01), Matsuda
Hamano Yohei
Ito Kenzo
Matsuda Hajime
Matsumoto Takashi
Minami Takashi
Kishore Gollamudi S.
Shiseido Co. Ltd.
Snider Ronald R.
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