Cholesterol biosynthesis inhibitors

Details Cholesterol biosynthesis inhibitors Cholesterol biosynthesis inhibitors

1977-09-19

1979-10-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 424180, C07H 1700

Patent

active

041699440

ABSTRACT:
Cholesterol biosynthesis inhibitors are described which are derivatives of coenzyme A having the general formula ##STR1## wherein n is 1 to 3, inclusive, and CoA is coenzyme A minus a hydrogen atom from a sulfhydryl substituent. They are produced by reacting coenzyme A with a fluorinated 3-hydroxy-3-methylglutaric anhydride of the general formula ##STR2## in dilute aqueous alkali.

REFERENCES:
patent: 2550141 (1951-04-01), Doumani
patent: 3036093 (1962-05-01), Lynn
patent: 3402194 (1968-09-01), Schleppnik
Chem. Abstracts, 85, 1651e.
General Biochemistry, John Wiley & Sons, Inc., 1958, p. 510.
Chem. Abstracts, 85, 155390f.

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