Cholesterol and hedgehog signaling

Details Cholesterol and hedgehog signaling Cholesterol and hedgehog signaling

2003-05-20

2011-12-13

Epps-Smith, Janet L (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C435S006130, C435S006170

Reexamination Certificate

active

08076073

ABSTRACT:
The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.

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