Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-10-13
1996-09-24
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4352402, 536 232, 536 241, C12N 1511, C12N 1518, C12N 1555, C12Q 168
Patent
active
055589995
ABSTRACT:
DNA regulatory elements that control cholesterol 7.alpha.-hydroxylase expression are disclosed. A gene construct is provided comprising at least one regulatory element and a reporter gene is used in an assay to detect a compound that modulates cholesterol 7.alpha.-hydroxylase enzyme regulation. Thus, a method for screening compounds that inhibit or stimulate expression of the enzyme is provided, as well as a method for detecting and isolating the transcription factors of the cholesterol 7.alpha.-hydroxylase gene.
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Carter Philip W.
Fleisher Mindy
Northeastern Ohio Universities
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