Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-08-21
1993-12-14
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, A61K 31335, C07D31908
Patent
active
052703320
ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. The compounds also exhibit antifungal activity and are inhibitors of farnesyl-protein transferase.
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Baxter et al., J. Biol. Chem. vol. 267, 11705-11708 (1992).
Sidebottom et al., J. Antibiotics, 45, 648-657 (May 1992).
Chen Shieh-Shung T.
Huang Leeyuan
MacConnell John G.
Polishook Jon D.
White Raymond F.
Chan Nicky
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Winokur Melvin
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