Cholera vaccines

Details Cholera vaccines Cholera vaccines

1992-03-23

1994-07-19

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4242001, 4242361, 4242421, 4242611, 514 2, 514 12, 514 16, 530324, 530350, 530825, 536 237, C07K 1504, C07K 1300, A61K 39106

Patent

active

053307534

ABSTRACT:
The gene encoding the TcpA pilus has been cloned. It encodes a protein useful in live, killed-cell, and synthetic vaccines. Protein production is enhanced by specific medium conditions.

REFERENCES:
patent: 5098998 (1992-03-01), Mekalanos et al.
Infectous Dis. and Med. Microbiology, Braude, et al (eds). 1986 W. B. Saunders Co. pp. 303-310.
Sun, D., et al., Serodiagnosis and Immunotherapy in Infectious Disease 4:73-81 (1990), "Production and characterization of monoclonal antibodies to the toxin coregulated pilus (TCP) of Vibrio cholerae that protect against experimental cholera in infant mice".
Sun, D., et al., Infection and Immunity 59(1):114-118 (1991), "Localization of Protective Epitopes within the Pilin Subunit of the Vibrio cholerae Toxin-coregulated Pilus".
Ehara, M., et al. Trop Med. 28(1):21-34 (1986), "Fimbriae of Vibrio-cholerae 0-1 observation of fimbriae on the organisms adherent to the intestinal epithelium and development of a new medium to enhance fimbriae production" (BIOSIS 82093678 abstract only).
Taylor, R. K., et al., Ann Sclavo 0(1-2):51-62 (1986), "Identification of a pilus colonization factor that is coordinately regulated with cholera toxin." (BIOSIS 34094439 abstract only).
Yamamoto, T., et al., J. Bacteriology 169(3):1352-57 (1987), "Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia-coli and Vibrio cholerae" (BIOSIS 83107075 abstract only).

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