Cholera toxin gene regulated by tissue-specific promoters

Details Cholera toxin gene regulated by tissue-specific promoters Cholera toxin gene regulated by tissue-specific promoters

1993-03-25

1995-05-16

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352404, 4353201, 4352523, 536 237, 536 241, C12N 510, C12N 1531, C12N 1511, C12N 1585

Patent

active

054160170

ABSTRACT:
The present invention contemplates a method of physiologic engineering by genetically altering second messenger levels in cells. This method allows the hyperactivation or inhibition of cell function within cells, tissues and animals by introducing a foreign gene that alters a second messenger system. The use of physiologically engineered animals as systems for determining the effectiveness of therapeutic compositions is also contemplated.

REFERENCES:
patent: 5223610 (1993-06-01), Burton et al.
Behringer, et al., Genes & Devel. 2: 453-461 (1988).
Palmiter, et al., Cell 50: 435-443 (1988).
Brinster, et al., Cell 27: 223-231 (1981).
Mekalanos, ete al., Nature 306: 551-557 (1983).

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