Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-06-26
2007-06-26
Qazi, Sabiha N. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S231200, C544S099000, C544S106000, C540S098000, C540S099000
Reexamination Certificate
active
09630546
ABSTRACT:
Novel sterol derivatives of formula (I), in which: R1represents a hydroxyl group or protected hydroxyl group, R2represents a hydrogen atom and a double bond is present at c, or R1and R2together represent an oxo group and a double bond is present at b or double bonds are present at a and b; R3represents a methyl group having α- or β-configuration; R4and R5, which may be the same or different, are selected from hydrogen atoms and aliphatic, cycloaliphatic, araliphatic and aryl groups, or together with the nitrogen atom to which they are attached form a heterocyclic group; and X represents a polymethylene group containing 2–5 carbon atoms, an oxa group-containing analogue thereof in which a methylene group other than that attached to the —CO.NR4R5moiety is replaced by an oxygen atom, or an unsaturated analogue thereof containing up to two double bonds. Active compounds of the invention exhibit potent effects on the modulation of cell growth and differentiation and possess an advantageous therapeutic ratio by virtue of their low levels of calcaemic activity.
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Hesse Robert Henry
Ramgopal Malathi
Setty Sundara Katugam Srinivasasetty
Bacon & Thomas PLLC
Qazi Sabiha N.
Research Institute for Medicine and Chemistry, Inc.
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