Cholecystokinin antagonists useful for treating depression

Details Cholecystokinin antagonists useful for treating depression Cholecystokinin antagonists useful for treating depression

1991-08-20

1993-06-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514530, 530330, 530331, A61K 31405, C07D20920, C07D40312

Patent

active

052179575

ABSTRACT:
The invention concerns cholecystokinin (CCK) antagonists useful in the treatment major and minor forms of depression. CCK-B, -A, and mixed -A and -B antagonists are useful. Especially useful are CCK.sub.B antagonists such as CI-988.

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Berkow, editor "The Merck Manual of Diagnosis and Therapy", Fourteenth Edition, Published by Merck Sharp & Dohme Research Laboratories division of Merck & Co., Inc. Rahway, N.J., 1982, pp. 1448-1463.
Yu et al., "Quinazolinone Cholecystokinin-B-Receptor Ligands," J. Med. Chem. 1991, 34, pp. 1505-1508.
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de Montigny, "Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers," ARCH, GEN PSYCHIATRY, vol. 46, Jun. 1989, pp. 511-517.
Annu. Rev. Pharmacol. Toxicol., 1991, 31:469-501 "Cholecystokinin Antagonists", G. N. Woodruff et al.
Proc. Natl. Acad. Sci. USA, vol. 87, pp. 6728-6732 Sep. 1990, "Development of a Class . . . Cholecystokinin . . . ", J. Hughes et al.
Proc. Natl. Acad. Sci. USA, vol. 88, pp. 1130-1133, Feb. 1991, "Evidence for . . . Cholecystokinin B . . . " L. Singh et al.
Nature vol. 266, 21 Apr. 1977, pp. 730-732, "Depression: A New Animal Model . . . ", R. D. Porsolt, et al.

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